Program 04 · Expression design · NEXUS research studio v1.0

RNA Construct Strategy Studio

Research-stage construct strategies for miRNA, small activating RNA, cytoplasmic and membrane mRNA, self-amplifying RNA, and CAR expression. Build conceptual maps, assess design risks, and export a validation plan.

Six distinct modalitiesArchitecture diagramsModality-specific QCJSON exportNew: coding & UTR designerNew: DBTL & Protein Structure

Choose expression modality

Compare molecular architectures and stage-appropriate verification plans. For non-amplifying, protein-coding mRNA sequence hypotheses, use the DBTL & Structure Intelligence Workbench ↗ or the Coding + 5′/3′ UTR Design Workbench ↗.

Optional reference length; not a computed final RNA length.

For protein-coding RNA only; separate SeqFold tool.

saRNA is ambiguous: small activating RNA (RNAa) and self-amplifying RNA are separate modalities. No guide RNA, replicase, CAR, or clinical construct sequences are generated here.

Conceptual architecture

Diagram shows functional modules; not proportional, sequence-validated, or an assembly protocol.

Independent validation priorities

    Biological design interpretation

      Review flags

        Downstream tools and evidence

        Use the complementary studios after establishing a defensible construct design and assay plan.

        Research-only architecture options require sequence-specific QC, applicable IP/FTO review, safety and performance testing in an appropriate regulated setting. No claims of expression, efficacy, or manufacturability are made.